Paxlovid consists of two medications, Nirmatrelvir, and Ritonavir. Nirmatrelvir is an antiviral medication intended to curb viral replication. Ritonavir slows down the breakdown of Nirmatrelvir to increase the amount of Nirmatrelvir in the blood.

If you have diabetes, high blood pressure, or high cholesterol, Paxlovid may not be the right medication. Be sure to talk to your pharmacist or doctor about any other medications you are taking before starting Paxlovid.

How should I take Paxlovid?

When prescribed, take Paxlovid twice a day for 5 days. It is best to take Paxlovid as soon as you feel symptoms.

When should I be careful taking Paxlovid?

Paxlovid can interact with certain medications you take for diabetes, high blood pressure, or cholesterol. Some medications that may interact with Paxlovid are listed below but note that this list is not comprehensive. It's important to tell your doctor about all the drugs and supplements you take to rule out interactions. Use the interaction checker to search for additional information.

Stop taking these drugs while on Paxlovid:

  • Aliskiren (Tekturna): Do not use with Paxlovid; restart after 3 to 5 days of your last Paxlovid dose.
  • Atorvastatin (Lipitor): Stop taking Atorvastatin while taking Paxlovid.
  • Lovastatin: Do not use with Paxlovid; restart after 3 to 5 days of your last Paxlovid dose.
  • Rosuvastatin (Crestor): Stop taking Rosuvastatin while taking Paxlovid.
  • Simvastatin (Zocor): Do not use with Paxlovid; restart after 3 to 5 days of your last Paxlovid dose.
  • Saxagliptin (Onglyza): Do not take it while taking Paxlovid.

Monitor your symptoms when taking these meds with Paxlovid:

  • Amlodipine (Norvasc): May cause a further drop in blood pressure; monitor for symptoms.
  • Diltiazem (Cardizem): May cause a further drop in blood pressure; monitor for symptoms.
  • Felodipine: May cause a further drop in blood pressure; monitor for symptoms.
  • Nifedipine (Procardia): May cause a further drop in blood pressure; monitor for symptoms.
  • Pioglitazone (Actos): Low risk of an interaction
  • Valsartan (Diovan): May cause a further drop in blood pressure; monitor for symptoms.
  • Verapamil: May cause a further drop in blood pressure; monitor for symptoms.

Talk to your 9am Care Team about any concerns you may have. They can help you navigate your medications. They can also answer any questions that might come up.

References: Liverpool